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Case history of Haemoblock as a local hemostatic agent in oculoplastic surgery

Intraoperative hemostasis is an important stage of oculoplastic surgical procedure. Current physical and mechanical methods of bleeding control showed good results in oculoplastic surgery. They are widely used, however, they may be inconvenient for some types of surgical procedures. Thus, for example, capillary bleeding from small vessels is observed after every discission on eyelids. In case of electrocoagulation and radiofrequency methods application for hemostasis one should influence on
every bleeding vessel in turn, and it results in more scars in the postoperative period. Hence, application of Haemoblock hemostatic agent of local application is rather interesting. Recent studies prove the effectiveness of Haemoblock in obstetrics, gynecology, general surgery and dentistry. Its formula includes partial silver salt of polyacrylic acid, with integrated silver nanoparticles. The substance is applied topically in cases of parenchymal and capillary hemorrhage. Sterile cotton wool or gauze
tampons are soaked with the substance and applied to the bleeding, preliminarily dried up surface of the wound, or it is sprayed on the wound [3]. The hemostatic effect is achieved due to the formation of a clot with plasma proteins (mainly, albumin) by Haemoblock. During the first stage of the medical substance action, a polyacrylic matrix structure is formed which contains albumin molecules in the cells of polyacrylic matrix. This structure is a primary organizer of a sustainable film. Then, the silver ions are
restored by albumin molecules, forming a sustainable set: polyacrilate anions form a strong bond with positively charged albumin molecules. Such structure is packed in several micro-layers, creating a strong polymethacrylate film on the wound surface. At a later stage the surface Haemoblock-protein structure is replaced by fibrin. Whereas the polyacrylate matrix is plasmolysed within 24 hours. Silver nanoparticles produce a great antibacterial effect against the most known gram-positive and gramnegative bacteria such as Streptococcus spp., Staphylococcus spp., Moraxella spp., and etc., and mycology (Candida spp., etc.)